Projects and Questions

We study the immune system in the context of pregnancy and beyond with a combination of mouse models and human cells. To answer our questions, we lean on a variety of classical and novel techniques, such as multi-parameter flow cytometry and cell sorting, basic and flow-based biochemistry, (congenital) infectious models, ELISA, and bulk and single-cell transcriptomics, to name a few. Our current projects are below.

If our mission and these projects sound interesting to you, we are actively recruiting motivated technicians, graduate students, and postdoctoral researchers! To inquire about or apply for a position, please contact Scott directly.

Innate immune activation and function in (congenital) infection

• Which immune mediators damage the fetus and cause devastating fetal/neonatal outcomes?

• How do innate immune cells coordinate the adaptive immune response in

Classical and non-classical responders to Interleukin 15

Publications

2020

Scott M. Gordon, Mailyn A. Nishiguchi, Julie M. Chase, Sneha Mani, Monica A. Mainigi and Edward M. Behrens: IFNs Drive Development of Novel IL-15-Responsive Macrophages. The Journal of Immunology 205(4): 1113-1124. 2020.

Scott M. Gordon, Lakshmi Srinivasan, Deanne M. Taylor, Stephen R. Master, Marissa A. Tremoglie, Adriana Hankeova, Dustin D. Flannery, Soraya Abbasi, Julie C. Fitzgerald and Mary C. Harris: Derivation of a metabolic signature associated with bacterial meningitis in infants. Pediatric Research 88(2): 184-191. 2020.

Liza Johannesson, Giuliano Testa, Rebecca Flyckt, Ruth Farrell, Cristiano Quintini,  Anji Wall, Kathleen O'Neill, Andreas Tzakis, Elliott G. Richards, Scott M. Gordon and Paige M. Porrett: Guidelines for Standardized Nomenclature and Reporting in Uterus Transplantation: An Opinion From the United States Uterus Transplant Consortium. American Journal of Transplantation 20: 3319–3325. 2020.

2017

Scott M. Gordon, Laskshmi Srinivasan and Mary C. Harris: Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. Frontiers in Pediatrics 5(139), 2017.

2013

Michael A. Paley, Scott M. Gordon, Elizabeth K. Bikoff, Elizabeth J. Robertson, E. John Wherry, Steven L. Reiner: Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes. Journal of Leukocyte Biology 93(2): 307-15. 2013.

2012 

Scott M. Gordon, Julie Chaix, Levi J. Rupp, Junmin Wu, Sharline Madera, Joseph C. Sun, Tullia Lindsten and Steven L. Reiner. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 36(1): 55-67. 2012.

2011

Scott M. Gordon, Shannon A. Carty, Jiyeon S. Kim, Tao Zou, Jennifer Smith-Garvin, Eric S. Alonzo, Ethan Haimm, Derek B. Sant'Angelo, Gary A. Koretzky, Steven L. Reiner and Martha S. Jordan: Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. The Journal of Immunology 186(8): 4573-8. 2011.

Harry Z. Qui, Adam T. Hagymasi, Suman Bandyopadhyay, Marie-Clare St Rose, Raghunath Ramanarasimhaiah, Antoine Ménoret, Robert S. Mittler, Scott M. Gordon, Steven L. Reiner, Anthony T. Vella and Adam J. Adler: CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. The Journal of Immunology 187(7): 3555-64. 2011.

2010

Arnob Banerjee, Scott M. Gordon, Andrew M. Intlekofer, Michael A. Paley, Erin C. Mooney, Tulia Lindsten, E. John Wherry and Steven L. Reiner: Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. The Journal of Immunology 185(9): 4988-92. 2010.

Ichiko Kinjyo, Scott M. Gordon, Andrew M. Intlekofer, Kennichi Dowdell, Erin C. Mooney, Roberto Caricchio, Stephan A. Grupp, David T. Teachey, V. Koneti Rao, Tullia Lindsten, Steven L. Reiner: Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. The Journal of Immunology 185(12): 7151-5. 2010.

2008

Andrew M. Intlekofer, Arnob Banerjee, Naofumi Takemoto, Scott M. Gordon, Caitlin S. Dejong, Haina Shin, Christopher A. Hunter, E. John Wherry, Tullia Lindsten and Steven L. Reiner: Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 321(5887): 408-11. 2008.